Resist the Temptation of Response-Adaptive Randomization

Using Randomization Tests to Preserve Type I Error With Response-Adaptive and Covariate-Adaptive Randomization.

We demonstrate that clinical trials using response adaptive randomized treatment assignment rules are subject to substantial bias if there are time trends in unknown prognostic factors and standard methods of analysis are used. We develop a general class of randomization tests based on generating the null distribution of a general test statistic by repeating the adaptive randomized treatment as...

How to resist temptation: the effects of external control versus autonomy support on self-regulatory dynamics.

The purpose of the present study (N=80 undergraduate students) was to examine two issues: first, does external control lead to an increase in resistance to temptation more than the use of autonomy support? Second, what are the long-term effects of these types of educational style? Based on the Personality Systems Interaction (PSI) theory, external control was expected to increase resistance to ...

Effects of motivation and depletion on the ability to resist the temptation to avoid physical activity

Can response-adaptive randomization increase participation in acute stroke trials?

BACKGROUND AND PURPOSE A response-adaptive randomization (RAR) trial design actively adjusts the ratio of participants assigned to each trial arm, favoring the better performing treatment by using outcome data from participants already in the trial. Compared with a standard clinical trial, an RAR study design has the potential to improve patient participation in acute stroke trials. METHODS T...

A Graphical Method for Comparing Response-Adaptive Randomization Procedures

Abstract Response-adaptive randomization procedures have a dual goal of estimating the treatment effect and randomizing patients with a higher probability of receiving the superior treatment. These are competing objectives, and no procedure in the literature is “perfect” with respect to both objectives. For clinical trials of two treatments, we discuss metrics for comparing response-adaptive ra...